Organic Food and Health: A new project to study the effects of plant cultivation methods (organic and conventional) on nutritional value, health and reproduction in an animal experiment

Many consumers believe that food from plants grown under certain conditions, such as organic agriculture, will benefit health more than conventional food. This cannot be determined simply by analysing the material, since our understanding of the connections between food components and health is still to imprecise for such a purpose. Rather than waiting until basic research provides the knowledge needed for this approach, in the spring of 2001 we have initiated a project to study physiological effects of plant quality directly, in an animal experiment. The following cultivation treatments are used to grow plants that are typical ingredients for a human diet (potato, mature peas, kale, spring wheat, oilseed rape, carrots and apples): 1. A model of a distinct conventional cultivation system, with high input of mineral nutrients and use of as much pesticides as is allowed. 2. A model of a distinct organic cultivation system, with low input of organic plant nutrients and no use of pesticides. 3. A combination of model 1 and 2, with low input of nutrients and use of pesticides. The materials from each cultivation treatment will be thoroughly characterised, by measuring contents of nutrients (protein, minerals, energy content, vitamins), the biological value of major protein sources of feed plants will be assessed, selected secondary metabolites including known anti-nutrients will be measured and other quality indicators will be assessed including biocrystallization. Based on these results, 3 feed mixtures will be prepared, either based on defined weight percentages of each material from each treatment, or, if large variation in biological value is found, one or two feed mixtures can be adjusted to provide the same availability of protein and energy as the reference treatment (model 1). Potato, mature peas and kale will be cooked and freeze-dried, wheat is ground and baked to biscuits, oil is produced from the rapeseed, and raw carrots and apples are shredded and freeze dried, before feed pellets with the desired composition are prepared from the material. Three groups of rats are each provided one of the dietary treatments during 2.5 generation, and reproductive characteristics and performance are recorded. Subgroups of the last generation are selected for an intensive study in which uptake and excretion of energy and protein and selected micronutrients are determined. Respiration trials are performed to assess the energy metabolism, and simultaneous measurements of the activity levels of the rats are performed. In addition, blood and tissue samples of the rats will be obtained to study the effect of the dietary treatments on the immunological and antioxidant status of the rats. Data from the experiments are assembled and analysed using relevant statistical models, and the relationship to the nutritional characteristics of the plant material is described. Funding for the core project for a 4-year period is secured from the Danish Research Centre for Organic Farming (DARCOF). However, the intention is to provide a platform for international collaboration, since the well-documented material of plants and animals can provide multiple opportunities for associated projects. To investigate other aspects of plant composition or health than what is foreseen in the present project, or to follow up on it with additional experiments

Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1α and PDK4 mRNA response in trained human muscle

The aim of this study was to investigate the mRNA response related to mitochondrial biogenesis, metabolism, angiogenesis, and myogenesis in trained human skeletal muscle to speed endurance exercise (S), endurance exercise (E), and speed endurance followed by endurance exercise (S + E). Seventeen trained male subjects (maximum oxygen uptake (VO(2)‐max): 57.2 ± 3.7 (mean ± SD) mL·min(−1)·kg(−1)) performed S (6 × 30 sec all‐out), E (60 min ~60% VO(2)‐max), and S + E on a cycle ergometer on separate occasions. Muscle biopsies were obtained at rest and 1, 2, and 3 h after the speed endurance exercise (S and S + E) and at rest, 0, 1, and 2 h after exercise in E. In S and S + E, muscle peroxisome proliferator‐activated receptor‐γ coactivator‐1 (PGC‐1α) and pyruvate dehydrogenase kinase‐4 (PDK4) mRNA were higher (P < 0.05) 2 and 3 h after speed endurance exercise than at rest. Muscle PGC‐1α and PDK4 mRNA levels were higher (P < 0.05) after exercise in S + E than in S and E, and higher (P < 0.05) in S than in E after exercise. In S and S + E, muscle vascular endothelial growth factor mRNA was higher (P < 0.05) 1 (S only), 2 and 3 h after speed endurance exercise than at rest. In S + E, muscle regulatory factor‐4 and muscle heme oxygenase‐1 mRNA were higher (P < 0.05) 1, 2, and 3 h after speed endurance exercise than at rest. In S, muscle hexokinase II mRNA was higher (P < 0.05) 2 and 3 h after speed endurance exercise than at rest and higher (P < 0.05) than in E after exercise. These findings suggest that in trained subjects, speed endurance exercise provides a stimulus for muscle mitochondrial biogenesis, substrate regulation, and angiogenesis that is not evident with endurance exercise. These responses are reinforced when speed endurance exercise is followed by endurance exercise

Two Forms of Social Inequality in Students' Socio-Emotional Skills: Do the Levels of Big Five Personality Traits and Their Associations With Academic Achievement Depend on Parental Socioeconomic Status?

Some researchers and policymakers advocate a stronger focus on fostering socio-emotional skills in the hope of helping students to succeed academically, especially those who are socially disadvantaged. Others have cautioned that this might increase, rather than reduce, social inequality because personality traits conducive to achievement are themselves unevenly distributed in disfavor of socially disadvantaged students. Our paper contributes to this debate. Analyzing representative, large-scale data on 9,300 ninth graders from the German National Educational Panel Study (NEPS) and using the Big Five personality traits as a measure of socio-emotional skills, we cast light on two related yet distinct aspects of social inequality in socio-emotional skills: First, do levels of personality traits conducive to achievement vary as a function of students' parental socioeconomic status (pSES)? Second, do the returns to personality traits in terms of trait-achievement relations vary as function of pSES? Results showed that differences in Big Five traits between students with different pSES were small (0.04 ≤ |r| ≤0.09), especially when compared with pSES-related differences in cognitive skills (fluid intelligence) and sex-related differences in personality. The returns to Conscientiousness - the personality trait most relevant to achievement - in terms of its relations to academic achievement were higher in higher- vs. lower-SES students. Trait-achievement relations did not vary as a function of pSES for the other Big Five traits. Overall, both types of inequality were limited in magnitude. We discuss the implications of these findings for policy and practice and delineate directions for further research

Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS)

Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients. Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in Multiple Sclerosis (NCT01440062) baseline serum vitamin D levels were evaluated. Patients were dichotomized based on the definition of vitamin D deficiency which is reflected by a < 30 vs. ≥ 30 ng/ml level of 25-hydroxyvitamin D (25(OH)D). Possible associations between vitamin D deficiency and both clinical and MRI features of the disease were analyzed. Results: Median (25, 75% quartiles, Q) 25(OH)D level was 18 ng/ml (12, 24). Forty eight out of 53 (91%) patients had 25(OH)D levels < 30 ng/ml (p < 0.001). Patients with 25(OH)D ≥ 30 ng/ml had lower median (25, 75% Q) T2-weighted lesion counts [25 (24, 33)] compared to patients with 25(OH)D < 30 ng/ml [60 (36, 84), p = 0.03; adjusted for age, gender and disease duration: p < 0.001]. Expanded disability status scale (EDSS) score was negatively associated with serum 25(OH)D levels in a multiple linear regression, including age, sex, and disease duration (adjusted: p < 0.001). Interpretation: Most patients recruited in the EVIDIMS study were vitamin D deficient. Higher 25(OH)D levels were associated with reduced T2 weighted lesion count and lower EDSS scores

Sea-to-air and diapycnalnitrous oxide fluxes in the eastern tropical North Atlantic Ocean

Sea-to-air and diapycnal fluxes of nitrous oxide (N2O) into the mixed layer were determined during three cruises to the upwelling region off Mauritania. Sea-to-air fluxes as well as diapycnal fluxes were elevated close to the shelf break, but elevated sea-to-air fluxes reached further offshore as a result of the offshore transport of upwelled water masses. To calculate a mixed layer budget for N2O we compared the regionally averaged sea-to-air and diapycnal fluxes and estimated the potential contribution of other processes, such as vertical advection and biological N2O production in the mixed layer. Using common parameterizations for the gas transfer velocity, the comparison of the average sea-toair and diapycnal N2O fluxes indicated that the mean sea-toair flux is about three to four times larger than the diapycnal flux. Neither vertical and horizontal advection nor biological production were found sufficient to close the mixed layer budget. Instead, the sea-to-air flux, calculated using a parameterization that takes into account the attenuating effect of surfactants on gas exchange, is in the same range as the diapycnal flux. From our observations we conclude that common parameterizations for the gas transfer velocity likely overestimate the air-sea gas exchange within highly productive upwelling zones

Tunable absorption and emission wavelength in conjugated microporous polymers by copolymerization

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Conjugated, microporous polymers based on a spirobifluorene core were synthesized by Suzuki polycondensation of the tetrabromospirobifluorene with benzene diboronic acid and/or thiophene diboronic acid. The optical properties (absorption and emission spectra) and the gas sorption properties (N2 and CO2) are analyzed and discussed

Volitional action as perceptual detection: Predictors of conscious intention in adolescents with tic disorders

AbstractVoluntary actions are accompanied by a distinctive subjective experience, so that they feel quite different from physically similar involuntary movements. However, the nature and origin of this experience of volition remain unclear. Voluntary actions emerge during early childhood, in parallel with reduction of involuntary movements. However, the available markers of the experience of volition, notably Libet's mental chronometry of intention, cannot readily be used in young children. In Gilles de la Tourette syndrome (GTS), however, involuntary tic movements may coexist with voluntary control into adulthood. Therefore, adolescents with GTS could potentially confuse the two classes of movement. We have measured the temporal experience of voluntary action in a well-characterised group of adolescents with GTS, and age-matched controls. We replicated previous reports of a conscious intention occurring a few hundred milliseconds prior to voluntary keypress actions. Multiple regression across 25 patients' results showed that age and trait tic severity did not influence the experience of conscious intention. However, patients with stronger premonitory urges prior to tics showed significantly later conscious intentions, suggesting that the anticipatory experience of one's own volition involves a perceptual discrimination between potentially competing pre-movement signals. Patients who were more able to voluntarily suppress their tics showed significantly earlier conscious intention, suggesting that the perceptual discrimination between different action classes may also contribute to voluntary control of tics. We suggest that the brain learns voluntary control by perceptually discriminating a special class of internal ‘intentional’ signals, allowing them to emerge from motor noise